In addition to red blood cell reservoir of the virus may be endothelial cells of blood and lymph vessels, epithelial cells and related tissues, glacial cells of the nervous system and nerve cells. Routine AIDS psychosis and atrophy of the brain evolved precisely because of the ability of the virus to infect the central nervous system. The cells outside the vascular bed is not always a surface receptor proteins to the virus, which does not allow him adsorbed and penetrate the cell directly, but infection can occur if the merger with infected CD4-cells and macrophages.
Penetrating through the blood-brain barrier, the virus causes in the brain abnormal reproduction of glial cells surrounding the neurons, as well as the destruction occurring as a result of white matter brain development of primary brain lymphoma, and atrophy of certain nerves (vision in the first place).
The defeat of the nervous system indicated a third of AIDS patients and is manifested in four main clinical forms:
Brain abscesses (progressive nodal encephalopathy, streptococci meningitis, sub acute encephalitis may microdensitometer etiology.)
Swelling of the brain, such as primary and secondary brain lymphoma;
Vascular brain injury (brain hemorrhages) and heart (endocrinologist antibacterial thrombotic);
Focal brain lesions shells, characterized by self-meningitis.