Since it is not a 17 alpha alkylated compound, it can be used for a long period of time. The drug can even enhance potency of testosterone when used in an anabolic steroid cycle with it. The fact that GP Proviron can attach itself to SHBG (sex hormone-binding globulin) and albumin means that a large percentage of testosterone (free) is made available to conduct anabolic actions. Furthermore, the performance enhancing drug can also be used as an anti-aromatase and this characteristic proves to be beneficial when the drug is stacked with other anabolic steroids and performance enhancing drugs that may convert to estrogen to some extent. Since this steroid can bind to the aromatase enzyme, it does not allow steroids that are made a part of the cycle (with GP Proviron) to interact with enzymes and lead to formation of estrogens. Some sportsmen even use Mesterolone in an anabolic steroid cycle in place of testosterone that can have a negative effect on the libido since Proviron can enhance the level of libido to some extent because of the dihydrotestosterone effects of Mesterolone. A combined therapy with gonadotrophic hormone exhibiting follicle-stimulating hormone activity may be advised for initiating treatment and treatment with GP Proviron may be repeated after an interval of several weeks. It is important to note that use of Proviron is meant only for male patients though a medical practitioner may recommend its use to some female patients. When advised, individuals administered with it should undergo regular prostate examinations prophylactic-ally.
The increased level of free testosterone can then be utilized by the body for promoting protein synthesis that in turn stimulates muscle gain. Moreover, the steroid also has the ability to reduce the amount of free estrogen in the body by minimizing estrogen receptors’ ability to bind to estrogen. The drug is medically recommended to individuals suffering with potency disturbances due to androgen-deficiency, easy fatigability, lack of concentration, weak memory, disturbances of libido, depressive moods, general vegetative complaints, irritability, and declining physical activity and mental alertness in middle- and old-aged men. It may even be indicated for promoting the development of secondary male sex characteristics in cases of prepuberal hypogonadism and increasing fructose concentration up to normal values to enhance the chances of procreation.
The ideal dose of Mesterolone (GP Proviron) is 25-100 mg per day for men and 25 mg every day for women though some sportsmen, male as well as female, increase the doses to 50-125 mg every day and 40-60 mg per day, respectively. Tablets of Proviron should not be chewed and must always be swallowed with a full glass of water. Overdosing or abuse of this drug can lead to health complications such as oily skin, acne, exacerbation of male pattern baldness, growth of body/facial hair, deepening of the voice, and menstrual irregularities. The use of Mesterolone is not recommended to patients with carcinoma of the prostate or those who are undergoing androgen therapy of any kind, including the use of GP Proviron. In case a dose of this drug has been missed and it is almost time for the next dose, the first dose should be ignored and the next dose should be taken at the designated time. Under no circumstances, two doses of the drug should be taken together for the dose that was missed. Medical advice should be sought without any delay and use of GP Proviron should be stopped immediately if side effects such as pain in liver area, headache, loss of appetite, depression, unexplained weight loss, aggression, symptoms of an enlarged prostate (change in urination), acne or hirsutism are experienced.