Friday, April 3, 2015

Effect of Tamoxifen Citrate in bodybuilding life

When it comes to treating advanced breast cancer patients or reducing the side effects of estrogens while coming off their anabolic steroid cycle, Nolvadex, also known as Tamoxifen citrate. For on cycle gynecomastia prevention and post cycle therapy (PCT) needs Tamoxifen Citrate often fills the role of both for many performance enhancers across the board. For decades Tamoxifen Citrate has been a staple in many cycles in both men and women and for good reason; it works, it works well and is in most cases very well-tolerated.

By its mode of action Tamoxifen Citrate functions of the basis of two hormones, estrogen and testosterone, discouraging one while promoting the other. Belonging to a class of medications known as Selective Estrogen Receptor Modulators (SERM’s) Tamoxifen Citrate is not an anabolic steroid in any shape form or fashion, it does not perform in the traditional anabolic nature, although it can provide a secondary anabolic effect by its method of testosterone stimulation. Since Nolvadex has the ability of inhibiting the growth of tumors that respond to estrogens, it is one of the most popular drugs for treating node-positive breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. The antiestrogen is also recommended for treating metastatic breast cancer in women and men and Nolvadex is an alternative to oophorectomy or ovarian irradiation in premenopausal women with metastatic breast cancer. Medically, it is advised for the treatment of breast cancer that has spread to other parts of the body (metastatic breast cancer) and is also advised to treat breast cancer in certain patients after surgery and radiation therapy and may even be suggested to minimize the chances of breast cancer in high-risk patients.

For its testosterone stimulating properties this will be and is the main reason any anabolic steroid user will supplement with Tamoxifen Citrate and this will occur during the PCT period for men. When we supplement with anabolic steroids our natural testosterone production is suppressed and once the cycle is complete it is imperative that we once again stimulate natural testosterone production. This is very important to our overall health, as a well-functioning endocrine system is more than necessary; however it is also imperative to maintaining the gains made while on a cycle of anabolic steroids. While Tamoxifen Citrate therapy will not return natural testosterone production to its normal state during PCT use it will send you well on your way. A common misconception is that with a good PCT program our natural testosterone levels are normalized by this simple 3-4 week process, unfortunately this simply isn’t true. Assuming no more anabolic steroids are applied it can take several months for normal levels to be obtained even with Tamoxifen Citrate therapy; however, without therapy such normalization can take up to as much as a year or more depending on the individual at hand.

Beyond PCT needs Tamoxifen Citrate is often used as a means of gynecomastia prevention while on a cycle of anabolic steroids. Many anabolic steroids of an androgenic nature, such as testosterone will convert into estrogen after administration. Estrogen is an essential hormone for proper bodily function in-terms of sexual function, immune system and muscle growth, we do need some, however, as these levels increase it can become quite problematic. Many of the most commonly associated side-effects of anabolic steroid use are due to this conversion process brought on by the aromatase enzyme and as levels increase side-effects rear their head. A very common misconception is that Tamoxifen Citrate decreases estrogen in the body in the same fashion as many aromatase inhibitors; this is not true. While it will not reduce estrogen Tamoxifen Citrate will block it from binding to the receptors thereby preventing side-effects such as gynecomastia. Generally 10mg every day of the medication will prove to be useful for this end, however, for many no amount will be enough and only an aromatase inhibitor will prove to be effective.

While Tamoxifen Citrate was not created with performance enhancing in mind it is just that for which it is used most commonly and without question it has proven to be one of the most useful tools in the arsenal of any performance enhancer. Available in both tablet and liquid forms you simply drink there really aren’t too many downsides to this medication, in-fact, most well-planned cycles, be it for on cycle or PCT use will include Tamoxifen Citrate in them at some point and time as it is a highly necessary medication for most any athlete.

One of the biggest advantages of this antiestrogen is that patients whose tumors are estrogen receptor positive are more likely to benefit from it. In addition to that, it can minimize the occurrence of contralateral breast cancer in patients receiving adjuvant therapy for breast cancer. In women with Ductal Carcinoma in Situ (DCIS) after breast surgery and radiation, Nolvadex (Tamoxifen citrate) can minimize the risk of invasive breast cancer. It is worthwhile to note that Tamoxifen citrate is well tolerated in males with breast cancer and safety profile of the drug in males is similar to that noticed in women.

Sportsmen using anabolic steroids and performance enhancing drugs like Dianabol, Anadrol, and Testosterone derivatives often make use of Nolvadex (Tamoxifen citrate) and medical studies in the past have suggested that use of this antiestrogen is associated with dramatic improvements in levels of luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogen control.  Since use of Nolvadex is featured by its mild yet highly effective properties, it is often preferred compared to Arimidex, Femara and Aromasin since it does not prevent aromatization but plays the role of an estrogen antagonist, which is also useful in burning fat. The recommended dose of Nolvadex for patients with Ductal Carcinoma in Situ (DCIS) is 20 mg daily for 5 years while sportsmen on steroids use it in doses of 20-45 mg per day, with or without food.

Nolvadex (Tamoxifen citrate) abuse can lead to side effects, which may be mild or severe, including hypercalcemia, peripheral edema, distaste for food, pruritus vulvae, depression, dizziness, light-headedness, headache, hair thinning and/or partial hair loss, and vaginal dryness. In very rare cases, side effects like erythema multiforme, Stevens-Johnson syndrome, bullous pemphigoid, interstitial pneumonitis and rare reports of hypersensitivity reactions including angioedema may happen.

Women keen to use Tamoxifen citrate should avoid getting pregnant for two months after last stopping its use and others should best use birth control methods that don’t use hormones like diaphragms with spermicide or plain intrauterine devices (IUDs). Moreover, breast-feeding is not recommended while using this drug as it is unknown of Nolvadex passes into breast milk or may cause potential risk to the infant. Nolvadex (Tamoxifen citrate) is not recommended to individuals suffering with high amount of calcium in the blood, severely decreased platelets, decreased white blood cells, cataracts, problems with eyesight, blood clot in lung, stroke, obstruction of a blood vessel by a blood clot, blood clot in a deep vein, pregnancy, or a mother who is producing milk and breastfeeding. A loss of sexual ability or interest may occur in men making use of Nolvadex.

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