Wednesday, November 5, 2014

HIV-virus and making use of anabolic steroids

People who are suffering from the dreaded HIV-virus and making use of anabolic steroids to prevent AIDS wasting tend to gain modest gains in terms of muscle mass and weight, according to a new review.  Anabolic steroids are synthetic substances similar to the male sex hormone testosterone that promote growth of skeletal muscle and the development of male sexual characteristics. Although most recently in the news for their misuse by professional athletes, anabolic steroids have legitimate medical application for men with low testosterone and people with certain types of anemia. Two anabolic steroids available in the United States, Nandrolone Decanoate and Oxandrolone, have been used to help increase weight and muscle mass in small studies of people with wasting. Conversely, anabolic steroid use has been associated with increased rates of HIV in those who share needles or use non sterile needles when they inject steroids.

A synthetic anabolic steroid derived from Dihydrotestosterone, Winstrol or Stanozolol has been approved by the U.S. Food and Drug Administration for human use. This steroid with a high oral bioavailability survives first-pass liver metabolism when ingested because of a C17 a-alkylation.

Classified as a controlled substance under the Anabolic Steroids Control Act of 1990 and assigned to Schedule III, this drug has the chemical name of 17-methyl-2′ H -5(alpha)-androst-2-eno [3,2- c ]pyrazol-17(beta)-ol and the molecular weight of 344.5392 g/mol at the base.

Why Is Winstrol Used:
Winstrol is medically prescribed to treat anemia and hereditary angioedema. It is also recommended for improving muscle growth and increasing bone density. Winstrol may also be prescribed for improving the production of red blood cells in the body and stimulating the appetite of debilitated or weakened individuals. It may also be recommended to treat health conditions like urticaria, Raynaud’s phenomenon, cryptofibrinogenemia, and lipodermatosclerosis. Winstrol use can also be associated with strengthened tendons and ligaments and to increase lymphocyte count and CD8+ cell numbers and to decrease CD4+ and CD3+ in postmenopausal women who are diagnosed with autoimmune disorders or osteoporosis.

Winstrol is generally used by those into bodybuilding, athletics, and power lifting to lose fat while retaining lean muscle mass. Winstrol is commonly made a part of cutting cycles for preserving lean body mass while metabolizing adipose. Winstrol has the unique ability of reducing the level of sex hormone-binding globulin (SHBG) that binds to sex hormones for creating a positive and synergetic effect with other anabolic steroids used in an anabolic steroid cycle. This performance enhancing drug is also used by athletes to run faster and preserve muscle tissue during dieting. Winstrol is also admired in the bodybuilding circles for decreasing the level of high-density lipoproteins and increasing the level of low-density lipoproteins. This drug can even stimulate immediate-early gene expression in a manner that is independent of the androgen receptor.

In addition to these advantages, this drug is also used by athletes and bodybuilders because of its diuretic properties since Winstrol can improve the excretion of water from the body while improving body strength, without causing an increase in the level of body weight. Athletes absolutely admire this drug as it helps them utilize more amounts of testosterone for burning excess fat tissues and stimulates the production of prostaglandin E2 and the matrix metalloproteases collegenase and stromelysin in skin fibroblasts. The use of Winstrol can also be associated with the inhibition of growth factor stimulated DNA synthesis and fibroblasts.

Winstrol is ideally used by men in doses of 25-100 mg per day and 5-15 mg per day by women for a period not exceeding eight weeks at a stretch. This drug may be stacked for a bulking cycle with Testosterone, Dianabol or Anadrol or with Trenbolone or Halotestin during a dieting phase. A big majority of athletes even stack Winstrol with Equipoise, Deca Durabolin or Primobolan.

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